Synthetic introns enable highly specific targeting of cancer cells
Nature Biotechnology, Published online: 04 March 2022; doi:10.1038/s41587-022-01235-zA new method uses synthetic introns to express therapeutic proteins selectively in cells bearing cancer-initiating mutations affecting RNA splicing factors, while healthy cells remain unaffected. This approach enabled the eradication of human leukemia, breast cancer and uveal melanoma cells in mouse models and significantly prolonged host survival…
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