Identification of a chemical cocktail that drives the maturation of human neurons
Nature Biotechnology, Published online: 02 January 2024; doi:10.1038/s41587-023-02044-8The protracted timeline of maturation is a major bottleneck in generating adult-like neurons from human pluripotent stem cells. We identify a combination of four chemicals that promotes neuronal maturation by repressing epigenetic factors that inhibit it and stimulating activity-dependent factors that promote it…
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