Researchers discover ‘Humpty-Dumpty’ water-based mechanism of human sex reversal at edge of developmental ambiguity
Researchers from Indiana University School of Medicine have discovered a molecular “clamping” mechanism within a male-specific protein-DNA complex whose mutation causes sex reversal: children with XY chromosomes but female bodies, a condition called Swyer Syndrome. The clamp exploits a water molecule bridging the male factor (designated SRY) and DNA control sites at the tenuous beginnings of male development…
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