Synthetic biologics provide a path to target bHLH transcription factors
Nature Biotechnology, Published online: 03 November 2022; doi:10.1038/s41587-022-01509-6The ability to target the majority of human transcription factors remains an as yet unachieved goal in chemical biology and medicine. We developed a modular, synthetic transcriptional repressor platform that recapitulates the DNA-binding properties of native basic helix-loop-helix (bHLH) domains and can block the DNA-binding functions of an important oncogenic transcription factor target…
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